IFN-gamma deficiency worsen Pneumocystis pneumonia with Th17 development in nude mice.

@article{Hu2009IFNgammaDW,
  title={IFN-gamma deficiency worsen Pneumocystis pneumonia with Th17 development in nude mice.},
  author={Tao Hu and Masaya Takamoto and Sigeaki Hida and Yoh-ichi Tagawa and Kazuo Sugane},
  journal={Immunology letters},
  year={2009},
  volume={127 1},
  pages={
          55-9
        }
}
Pneumocystis pneumonia (PCP) occurs frequently in patients with immunodeficiency syndromes, especially AIDS. In order to investigate the role of IFN-gamma on PCP, nude mice deficient in IFN-gamma (GKO nude) and their wild-type ones (WT nude) were infected with murine Pneumocystis. Nine weeks later they were sacrificed, and cytokines in BALF and lung histopathology were compared between them. Cyst burden was greater in GKO than in WT nude mice. Histopathology in the lung was severer and… CONTINUE READING
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