IFN-gamma and TNF-alpha induce redistribution of PECAM-1 (CD31) on human endothelial cells.

@article{Romer1995IFNgammaAT,
  title={IFN-gamma and TNF-alpha induce redistribution of PECAM-1 (CD31) on human endothelial cells.},
  author={Lewis H. Romer and Natalie V. McLean and H. C. Yan and M Daise and Jiangfeng Sun and Horace M. Delisser},
  journal={Journal of immunology},
  year={1995},
  volume={154 12},
  pages={6582-92}
}
Platelet endothelial adhesion molecule-1 (PECAM-1/CD31) is a glycoprotein adhesion molecule of the Ig superfamily that is constitutively expressed on leukocytes, platelets, and endothelial cells where it concentrates at the intercellular borders of adjacent cells. Recent studies have confirmed that endothelial PECAM-1 is involved in the recruitment of neutrophils into inflammatory sites. However, the effects of inflammatory cytokines such as TNF-alpha and IFN-gamma on endothelial PECAM-1… CONTINUE READING

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