IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells.

@article{English2007IFNgammaAT,
  title={IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells.},
  author={Karen English and F Barry and Ciara P Field-Corbett and Bernard P. Mahon},
  journal={Immunology letters},
  year={2007},
  volume={110 2},
  pages={91-100}
}
Murine mesenchymal stem cells (MSC) have the ability to inhibit allogeneic immune responses. Two different mechanisms, either cell contact-dependent or independent, have been proposed to account for this immunosuppression. The focus of this study was to elucidate the involvement of soluble suppressive factors secreted by murine MSC in an inflammatory setting, and their role in MSC immunomodulation. In a non-inflammatory environment, bone marrow derived murine MSC constitutively expressed low… CONTINUE READING
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