IFN-gamma and T-bet expression in human dendritic cells from normal donors and cancer patients is controlled through mechanisms involving ERK-1/2-dependent and IL-12-independent pathways.

@article{Li2006IFNgammaAT,
  title={IFN-gamma and T-bet expression in human dendritic cells from normal donors and cancer patients is controlled through mechanisms involving ERK-1/2-dependent and IL-12-independent pathways.},
  author={Huifen Li and Wojciech Wojciechowski and Chiara Dell'agnola and Natalia E. Lopez and Igor Espinoza-Delgado},
  journal={Journal of immunology},
  year={2006},
  volume={177 6},
  pages={
          3554-63
        }
}
Dendritic cells (DC) play a major role in priming naive T cells and modulating the immune response. We have previously reported that bryostatin-1, a potent immune modulator with antitumor activity, activates monocytes and lymphocytes to produce cytokines. Studies have shown that tumor-bearing hosts have a Th1/Th2 cytokine pattern that is associated with decreased production of IFN-gamma. We investigated the expression of IFN-gamma in bryostatin-1-treated human DC. Bryostatin-1 induced both IFN… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-5 of 5 citations