IFN-gamma and IL-10 mediate parasite-specific immune responses of cord blood cells induced by pregnancy-associated Plasmodium falciparum malaria.

@article{Brustoski2005IFNgammaAI,
  title={IFN-gamma and IL-10 mediate parasite-specific immune responses of cord blood cells induced by pregnancy-associated Plasmodium falciparum malaria.},
  author={Kim Brustoski and Ulrike Moeller and Martin Kramer and Annika Petelski and Stephan Brenner and Dupeh R. Palmer and Martina Bongartz and Peter Gottfried Kremsner and Adrian J F Luty and Urszula Krzych},
  journal={Journal of immunology},
  year={2005},
  volume={174 3},
  pages={1738-45}
}
Available evidence suggests that immune cells from neonates born to mothers with placental Plasmodium falciparum (Pf) infection are sensitized to parasite Ag in utero but have reduced ability to generate protective Th1 responses. In this study, we detected Pf Ag-specific IFN-gamma(+) T cells in cord blood from human neonates whose mothers had received treatment for malaria or who had active placental Pf infection at delivery, with responses being significantly reduced in the latter group… CONTINUE READING