IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site.

@article{Canto2001IFNgammaAI,
  title={IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site.},
  author={Albert J. Dal Canto and Paul E. Swanson and Andrew K. O'Guin and Samuel H Speck and Herbert W Virgin},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 2},
  pages={R15-22}
}
Infection of medial smooth muscle cells with gamma-herpesvirus 68 (gammaHV68) causes severe chronic vasculitis that is restricted to the great elastic arteries. We show here that persistence of disease in the great elastic arteries is (a) due to inefficient clearance of viral infection from this site compared with other organs or other vascular sites, and (b) associated with failure of T cells and macrophages to enter the virus-infected elastic media. These findings demonstrate immunoprivilege… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Editorial commentary: varicella zoster virus infection: generally benign in kids, bad in grown-ups.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…