IFN-g Potentiates Atherosclerosis in ApoE Knock-out Mice

  title={IFN-g Potentiates Atherosclerosis in ApoE Knock-out Mice},
  author={Sanjay Gupta and Anne Marie Pablo and Xian-cheng Jiang and Nan Wang and Alan Richard Tall and C. Barbara Schindler},
The early colocalization of T cells and the potent immunostimulatory cytokine IFNg to atherosclerotic lesions suggest that the immune system contributes to atherogenesis. Since mice with a targeted disruption of the apoE gene (apoE 0 mice) develop profound atherosclerosis, we examined the role of IFNg in this process. First, the presence of CD4 1 and CD8 1 cells, which secrete lesional IFNg , was documented in apoE 0 atheromata. Then, the apoE 0 mice were crossed with IFNg receptor (IFN g R) 0… CONTINUE READING
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Cellular and Molecular Immunology

  • A. Abbas, A. H. Lichtman, J. S. Pober
  • W.B. Saunders Co., Philadelphia,
  • 1991
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