IFN-beta provides immuno-protection in the retina by inhibiting ICAM-1 and CXCL9 in retinal pigment epithelial cells.

@article{Hooks2008IFNbetaPI,
  title={IFN-beta provides immuno-protection in the retina by inhibiting ICAM-1 and CXCL9 in retinal pigment epithelial cells.},
  author={John J. Hooks and Chandrasekharam N. Nagineni and Laura C. Hooper and Kozaburo Hayashi and Barbara Detrick},
  journal={Journal of immunology},
  year={2008},
  volume={180 6},
  pages={3789-96}
}
The retinal pigment epithelial (RPE) cell is a potent regulatory cell that facilitates normal physiologic processes and plays a critical role in a variety of retinal diseases. We evaluated IFN-beta production in human RPE cells through TLR signaling and investigated the effects of IFN-beta on RPE cells. RPE cells treated with poly(I:C) or infected with an… CONTINUE READING