IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide.

@article{Natsume2005IFNbetaDT,
  title={IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide.},
  author={Atsushi Natsume and Dai Ishii and Toshihiko Wakabayashi and Takaya Tsuno and Hisashi Hatano and Masaaki Mizuno and Jun Yoshida},
  journal={Cancer research},
  year={2005},
  volume={65 17},
  pages={7573-9}
}
Alkylating agents, such as temozolomide, are among the most effective cytotoxic agents used for malignant gliomas, but responses remain very poor. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. IFN-beta can act as a drug sensitizer, enhancing toxicity against a variety of neoplasias, and is widely used in combination with other antitumor agents such as nitrosoureas. Here, we show that IFN-beta sensitizes… CONTINUE READING

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IFN - b down - regulates the expressionofDNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide

  • A Natsume, D Ishii, T Wakabayashi, T Tsuno, MizunoM Hatano H
  • Cancer Res
  • 2005

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