IFN-alpha priming of human monocytes differentially regulates gram-positive and gram-negative bacteria-induced IL-10 release and selectively enhances IL-12p70, CD80, and MHC class I expression.

@article{Hermann1998IFNalphaPO,
  title={IFN-alpha priming of human monocytes differentially regulates gram-positive and gram-negative bacteria-induced IL-10 release and selectively enhances IL-12p70, CD80, and MHC class I expression.},
  author={Patrice Hermann and M. Rubio and Toshihiro Nakajima and Guy Delespesse and M Sarfati},
  journal={Journal of immunology},
  year={1998},
  volume={161 4},
  pages={
          2011-8
        }
}
Administration of IFN-gamma and IFN-alpha may protect or induce autoimmune diseases. Although the in vitro regulation of monokine secretion by IFN-gamma have been extensively studied, the regulatory function of IFN-alpha has not yet been elucidated. We compared IFN-alpha and IFN-gamma, added alone or simultaneously before bacterial stimulation, for the control of monokine release and the expression of costimulatory molecules by human monocytes. Our data show that: 1) IFN-alpha primes monocytes… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

Cell Network of Pattern Recognition Receptors within a Induces IL-12 p 70 via Synergistic Activation Transfer RNA Mycobacterium tuberculosis

Caroline Keegan, Stephan Krutzik, +16 authors Robert L. Modlin
  • 2018
VIEW 8 EXCERPTS
HIGHLY INFLUENCED