IFN-alpha gene therapy for woodchuck hepatitis with adeno-associated virus: differences in duration of gene expression and antiviral activity using intraportal or intramuscular routes.

@article{Berraondo2005IFNalphaGT,
  title={IFN-alpha gene therapy for woodchuck hepatitis with adeno-associated virus: differences in duration of gene expression and antiviral activity using intraportal or intramuscular routes.},
  author={Pedro Berraondo and Laura Ochoa and Julien Crettaz and Fernando Rotellar and Africa Vales and Eduardo Mart{\'i}nez-Ans{\'o} and Mikel Zaratiegui and Juan Carlos Ruiz and Gloria Gonz{\'a}lez-Aseguinolaza and Jes{\'u}s Prieto},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2005},
  volume={12 1},
  pages={
          68-76
        }
}
Gene delivery of IFN-alpha to the liver may represent an interesting strategy to maximize its antiviral efficacy and reduce side effects. We used a recombinant adeno-associated virus (AAV) encoding woodchuck IFN-alpha (AAV-IFN) to treat animals with chronic woodchuck hepatitis virus infection. The vector was given by intraportal or intramuscular route. Long-term transgene expression was detected after intraportal administration of an AAV encoding luciferase. In contrast, in the majority of the… CONTINUE READING

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