IFN-alpha enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells.

@article{Luft2002IFNalphaEC,
  title={IFN-alpha enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells.},
  author={Thomas Schneider Luft and Petra Luetjens and Hubertus Hochrein and Tracey Toy and K Benjamin Masterman and Mark Rizkalla and Charlie Maliszewski and Ken D Shortman and Jonathan Cebon and Eugene Maraskovsky},
  journal={International immunology},
  year={2002},
  volume={14 4},
  pages={
          367-80
        }
}
Type I IFN are immune modulatory cytokines that are secreted during early stages of infection. Type I IFN bridge the innate and the adaptive immune system in humans and mice. We compared the capacity of type I and II IFN to induce the functional maturation of monocyte-derived dendritic cells (MoDC). Extending our earlier observation that type I IFN promote DC maturation, we report that these cytokines also enhance DC differentiation by augmenting CD40 ligand (CD40L)-induced cytokine secretion… CONTINUE READING

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