IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines.

@article{Cho2002IFNalphaBP,
  title={IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines.},
  author={Hearn Jay Cho and Tomoko Hayashi and Sandip K Datta and Kenji Takabayashi and John Henry Van Uden and Anthony Adam Horner and Maripat Corr and Eyal Raz},
  journal={Journal of immunology},
  year={2002},
  volume={168 10},
  pages={4907-13}
}
Immunostimulatory sequence (ISS) DNA containing unmethylated CpG dinucleotides stimulate NK and APC to secrete proinflammatory cytokines, including IFN-alphabeta and -gamma, TNF-alpha, and IL-6 and -12, and to express costimulatory surface molecules such as CD40, B7-1, and B7-2. Although ISS DNA has little direct effect on T cells by these criteria, immunization of wild-type mice with ISS DNA and OVA results in Ag-specific CTL and Th1-type T helper activity. This investigation examines the… CONTINUE READING