IFN-alpha beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection.

@article{Rothfuchs2001IFNalphaBI,
  title={IFN-alpha beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection.},
  author={Antonio C. Gigliotti Rothfuchs and Dario G. Gigliotti and Karin Palmblad and Ulf Andersson and Hans Wigzell and Martin E Rottenberg},
  journal={Journal of immunology},
  year={2001},
  volume={167 11},
  pages={6453-61}
}
Several reports have indicated that cell lineages apart from NK and T cells can also express IFN-gamma. However, the biological relevance of this finding is uncertain. We show in this study that bone marrow-derived macrophages (BMMs) express IFN-gamma at the mRNA and protein level early after infection with Chlamydia pneumoniae. Increased IFN-gamma mRNA accumulation by infected BMMs is early, transient, and requires both bacterial and host protein synthesis. The induction of IFN-gamma mRNA… CONTINUE READING

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