IFN Regulatory Factor 8 Is a Key Constitutive Determinant of the Morphological and Molecular Properties of Microglia in the CNS

@inproceedings{Minten2012IFNRF,
  title={IFN Regulatory Factor 8 Is a Key Constitutive Determinant of the Morphological and Molecular Properties of Microglia in the CNS},
  author={Carsten Minten and Rachael L. Terry and C{\'e}line Deffrasnes and Nicholas J. C. King and Iain L Campbell},
  booktitle={PloS one},
  year={2012}
}
IFN regulatory factor (IRF) 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation. Whether IRF8 plays a role in the development and function of microglia, the tissue-resident myeloid cells of the brain, is unknown. Here, we show IRF8 is a constitutively produced nuclear factor in microglia, which suggested that IRF8 might also be a key homeostatic transcriptional determinant of the microglial cell phenotype. In support… CONTINUE READING

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The Genetic Association of Variants in CD 6 , TNFRSF 1 A and IRF 8 to Multiple Sclerosis : A Multicenter Case - Control Study

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