IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex

  title={IFN-$\lambda$s mediate antiviral protection through a distinct class II cytokine receptor complex},
  author={Sergei V Kotenko and Grant E. Gallagher and Vitaliy V. Baurin and Anita Lewis-Antes and Meiling Shen and Nital K. Shah and Jerome A. Langer and Faruk G. Sheikh and Harold L. Dickensheets and Raymond P. Donnelly},
  journal={Nature Immunology},
We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-λ1 (IFN-λ1), IFN-λ2 and IFN-λ3 (tentatively designated as IL-29, IL-28A and IL-28B, respectively, by HUGO). The expression of IFN-λ mRNAs was inducible by viral infection in several cell lines. We identified a distinct receptor complex… 
Interferon-λ Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family*
The data show that, although IFN-λ is functionally an interferon, it is clearly structurally related to members of the IL-10 family, and it is suggested that IFn-λ and IL-22 possess parallel functions, protecting epithelial tissue against viral and bacterial infections, respectively.
Interferons : between structure and function
A high level of antiviral protection is achieved byIFN-α, IFN-β and IFN -λ, which act on receptors formed by λR1 IFN and IL-10R2 subunits.
Successful cloning and expression IFN-λ1 can be the first step for more production and further investigation about other activities of this cytokine and provides grounds for research on obtaining new therapeutic approaches for cancer, viral, autoimmune and allergic disease and designing more effective vaccines.
SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)–induced gene expression in vivo
It is found that IFN-α signaling is transient and becomes refractory after hours, whereas IFn-λ provides a long-lastingIFN-stimulated gene induction, the basis for the distinct kinetic properties of type I and III IFNs.
Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs
Critically review the recent literature on immune modulatory roles for IFN-λ, and distinguish between the direct and indirect effects of this IFN on immune cell functions in different inflammatory settings.
Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
The data demonstrate IFN-λ3 directly interacts with the human adaptive immune system, unlike what has been previously shown in published mouse models, and that type III IFNs could be potentially utilized to suppress both mucosal and blood-borne viral infections.
Interferon Lambda: Toward a Dual Role in Cancer.
New evidence and potential consequences associated with the biology of IFN-λ are discussed and a different vision for building novel therapeutic strategies in oncology is provided.


Interferon Signaling Is Dependent on Specific Tyrosines Located within the Intracellular Domain of IFNAR2c
Results indicate that IFN-dependent signaling proceeds through the redundant usage of two tyrosine residues in the cytoplasmic domain of IFNAR2c.
Interaction between the Components of the Interferon γ Receptor Complex (*)
It is shown that the intracellular domain of IFN-γR2 is necessary for signaling as measured by MHC class I antigen induction.
Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes
Signal transduction through receptors for interferons Type I and Type II, and interleukin 10 (IL-10) is described in detail, and a complex between tissue factor and coagulation factor VIIa, and two new receptors related to the class II cytokine receptor family are discussed.
Interferon-κ, a Novel Type I Interferon Expressed in Human Keratinocytes*
Interferon-κ therefore defines a novel subclass of type I interferon that is expressed in keratinocytes and expands the repertoire of known proteins mediating host defense.
Identification of the Functional Interleukin-22 (IL-22) Receptor Complex
Sharing of the common IL-10R2 chain between the IL- 10 and IL-TIF receptor complexes is the first such case for receptor complexes with chains belonging to the class II cytokine receptor family, establishing a novel paradigm for IL-9-related ligands similar to the shared use of the gamma common chain by several cytokines.
The interleukin-10 family of cytokines.
The intracellular domain of interferon-alpha receptor 2c (IFN-alphaR2c) chain is responsible for Stat activation.
It is demonstrated that Stat recruitment is solely a function of the IFN-alphaR2c intracellular domain, necessary and sufficient to activate Stat1, Stat2, and Stat3 proteins.
Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ*
It is demonstrated that Jak2 activation is not an absolute requirement for IFN-γ signaling and that Jaks are interchangeable and indiscriminative in the Jak-Stat signal transduction pathway.
Antiviral Actions of Interferons
  • C. Samuel
  • Biology
    Clinical Microbiology Reviews
  • 2001
SUMMARY Tremendous progress has been made in understanding the molecular basis of the antiviral actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the actions of
Identification and functional characterization of a second chain of the interleukin‐10 receptor complex
The CRFB4 chain, which is designated as the IL‐10R2 or IL‐ 10Rβ chain, serves as an accessory chain essential for the activeIL‐10 receptor complex and to initiate IL‐8‐induced signal transduction events.