IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex

@article{Kotenko2003IFNsMA,
  title={IFN-$\lambda$s mediate antiviral protection through a distinct class II cytokine receptor complex},
  author={Sergei V Kotenko and Grant E. Gallagher and Vitaliy V. Baurin and Anita Lewis-Antes and Meiling Shen and Nital K. Shah and Jerome A. Langer and Faruk G. Sheikh and Harold L. Dickensheets and Raymond P. Donnelly},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={69-77}
}
We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-λ1 (IFN-λ1), IFN-λ2 and IFN-λ3 (tentatively designated as IL-29, IL-28A and IL-28B, respectively, by HUGO). The expression of IFN-λ mRNAs was inducible by viral infection in several cell lines. We identified a distinct receptor complex… 
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