IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex

@article{Kotenko2003IFNsMA,
  title={IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex},
  author={Sergei V. Kotenko and Grant Gallagher and Vitaliy V. Baurin and Anita Lewis-Antes and Meiling Shen and Nital K. Shah and Jerome A. Langer and Faruk G Sheikh and Harold L. Dickensheets and Raymond P Donnelly},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={69-77}
}
We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-λ1 (IFN-λ1), IFN-λ2 and IFN-λ3 (tentatively designated as IL-29, IL-28A and IL-28B, respectively, by HUGO). The expression of IFN-λ mRNAs was inducible by viral infection in several cell lines. We identified a distinct receptor complex… CONTINUE READING
Highly Influential
This paper has highly influenced 20 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
143 Citations
52 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 143 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

interferon? Variety in the production of interferon in response to viral infection

  • Levy, D.E..Whence
  • J. Exp. Med. 195,
  • 2002

related, but to what extent? Cytokine Growth Factor Rev

  • Kotenko, S.V.The family of IL10-related cytokines, their receptors
  • 13, 223–240
  • 2002

Similar Papers

Loading similar papers…