IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex

  title={IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex},
  author={Sergei V. Kotenko and Grant Gallagher and Vitaliy V. Baurin and Anita Lewis-Antes and Meiling Shen and Nital K. Shah and Jerome A. Langer and Faruk G Sheikh and Harold L. Dickensheets and Raymond P Donnelly},
  journal={Nature Immunology},
We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-λ1 (IFN-λ1), IFN-λ2 and IFN-λ3 (tentatively designated as IL-29, IL-28A and IL-28B, respectively, by HUGO). The expression of IFN-λ mRNAs was inducible by viral infection in several cell lines. We identified a distinct receptor complex… CONTINUE READING
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