IFN-γ mediates early B-cell loss in experimental African trypanosomosis.

  title={IFN-γ mediates early B-cell loss in experimental African trypanosomosis.},
  author={Jennifer Cnops and Carl de Trez and Dubhe Bult{\'e} and Magdalena Radwanska and Bernhard Ryffel and Stefan Magez},
  journal={Parasite immunology},
  volume={37 9},
African trypanosomes infect humans and animals throughout the African continent. These parasites maintain chronic infections by various immune evasion strategies. While antigenic variation of their surface coat is the most studied strategy linked to evading the host humoral response, African trypanosomes also induce impaired B-cell lymphopoiesis, the destruction of the splenic B-cell compartment and abrogation of protective memory responses. Here we investigate the mechanism of follicular B… CONTINUE READING
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