IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments

@inproceedings{Vardjan2012IFNinducedII,
  title={IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments},
  author={Nina Vardjan and Mateja Gabrijel and Maja Potokar and Urban {\vS}vajger and Marko Kreft and Matja{\vz} Jeras and Yolanda de Pablo and Maryam Faiz and Milos Pekny and Robert Zorec},
  booktitle={Journal of Neuroinflammation},
  year={2012}
}
BackgroundIn immune-mediated diseases of the central nervous system, astrocytes exposed to interferon-γ (IFN-γ) can express major histocompatibility complex (MHC) class II molecules and antigens on their surface. MHC class II molecules are thought to be delivered to the cell surface by membrane-bound vesicles. However, the characteristics and dynamics of this vesicular traffic are unclear, particularly in reactive astrocytes, which overexpress intermediate filament (IF) proteins that may affect… CONTINUE READING
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