IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions.

@article{Kohara2011IFNDI,
  title={IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions.},
  author={Haruka Kohara and Hideki Kitaura and Yuji Fujimura and Masako Yoshimatsu and Yukiko Morita and Toshiko Eguchi and Ritsuko Masuyama and Noriaki Yoshida},
  journal={Immunology letters},
  year={2011},
  volume={137 1-2},
  pages={53-61}
}
Cytokines secreted by T cells play a pivotal role in inflammatory bone destruction. Tumor necrosis factor-α (TNF-α) is a major proinflammatory cytokine produced by macrophages following T cell activation, and directly promotes osteoclast differentiation resulting in accelerated bone resorption. Interferon-γ (IFN-γ) attenuates RANKL-initiated cellular signals through osteoclast formation and counterbalances aberrant bone resorption. With respect to this crosstalk during osteoclastogenesis, the… CONTINUE READING

From This Paper

Topics from this paper.
30 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…