IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo

  • Y Nakanishi, T Sato, K Takahashi, Toshiaki Ohteki
  • Published 2018 in Mucosal Immunology

Abstract

Colonic macrophages induce pathogenic inflammation against commensal bacteria, leading to inflammatory bowel disease (IBD). Although the ontogeny of colonic macrophages has been well studied in the past decade, how macrophages gain colitogenic properties during the development of colitis is unknown. Using a chemically induced colitis model, we showed that… (More)
DOI: 10.1038/mi.2017.104