IFN-γ and TNF-α Pre-licensing Protects Mesenchymal Stromal Cells from the Pro-inflammatory Effects of Palmitate.

@article{Boland2017IFNAT,
  title={IFN-γ and TNF-α Pre-licensing Protects Mesenchymal Stromal Cells from the Pro-inflammatory Effects of Palmitate.},
  author={Lauren K. Boland and Anthony J. Burand and Alex Joseph Brown and Devlin T. Boyt and Vitor A Lira and James A Ankrum},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2017},
  volume={26 3},
  pages={
          860-873
        }
}
The use of mesenchymal stromal cell (MSC) therapy for the treatment of type 2 diabetes (T2D) and T2D complications is promising; however, the investigation of MSC function in the setting of T2D has not been thoroughly explored. In our current study, we investigated the phenotype and function of MSCs in a simulated in vitro T2D environment. We show that palmitate, but not glucose, exposure impairs MSC metabolic activity with moderate increases in apoptosis, while drastically affecting… CONTINUE READING
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