IFN-γ Primes Macrophage Activation by Increasing Phosphatase and Tensin Homolog via Downregulation of miR-3473b

@article{Wu2014IFNPM,
  title={IFN-$\gamma$ Primes Macrophage Activation by Increasing Phosphatase and Tensin Homolog via Downregulation of miR-3473b},
  author={Cong Wu and Yiquan Xue and Pin Wang and Li Lin and Qiuyan Liu and Nan Li and Junfang Xu and Xuetao Cao},
  journal={The Journal of Immunology},
  year={2014},
  volume={193},
  pages={3036 - 3044}
}
The classical activation of macrophages, one of major innate effector cells, requires IFN-γ pretreatment (priming) and subsequent TLR stimuli (triggering). The priming effect of IFN-γ can promote macrophages to secrete higher level of proinflammatory cytokines but lower level of the anti-inflammatory cytokines, enhancing microbicidal and tumoricidal activity of macrophages. However, the underlying molecular mechanisms for IFN-γ–priming effect on macrophage activation remain to be fully… 

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