IFN-γ Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis

@inproceedings{Wensky2005IFNDD,
  title={IFN-γ Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis},
  author={Allen K. Wensky and Glaucia C Furtado and Maria Cecilia Garibaldi Marcondes and Shaohua Chen and Denise Manfra and Sergio A Lira and David Zagzag and Juan J Lafaille},
  year={2005}
}
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4+ T cells. EAE classically presents with a progressive ascending paralysis and is a model of multiple sclerosis that recapitulates some aspects of the disease. In this report we describe a mouse strain that spontaneously develops a severe, nonclassical form of EAE with 100% incidence. The distinct clinical phenotype is marked initially by a slight head tilt, progressing to a severe… CONTINUE READING

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