IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis.

@article{Zhao2018IFNRT,
  title={IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis.},
  author={Qing Zhao and Wenjing Cheng and Yebin Xi and Zheyi Cao and Yunzhi Xu and Ting Wu and Chengzhen Li and Xiaoyin Niu and Guangjie Chen},
  journal={Molecular immunology},
  year={2018},
  volume={93},
  pages={20-30}
}
Multiple sclerosis (MS) and the corresponding animal model, experimental autoimmune encephalomyelitis (EAE), are chronic neuroinflammatory autoimmune diseases. Increased activation of CD4+T cells, especially the Th1 and Th17 subsets, is thought to play a causal role in this disease. IFN-β is widely used in the treatment of MS and is found to decrease IL-17 and OPN production in MS patients and EAE mice. However, a definitive molecular mechanism has not yet been fully elucidated. In this study… CONTINUE READING