IFN-α-driven CCL2 Production Recruits Inflammatory Monocytes to Infection Site in Mice

@inproceedings{Conrady2013IFNdrivenCP,
  title={IFN-α-driven CCL2 Production Recruits Inflammatory Monocytes to Infection Site in Mice},
  author={Christopher D. Conrady and Min Zheng and Nawajes A. Mandal and Niko van Rooijen and Daniel J J Carr},
  booktitle={Mucosal Immunology},
  year={2013}
}
Herpes simplex virus type 1 (HSV-1) is the leading cause of corneal blindness in the developed world due to reactivation of infectious virus and the subsequent immune response. The innate response that facilitates viral control in the cornea is currently unknown. In the present study using a mouse chimera model, we found that a bone marrow component is crucial in inhibiting viral replication and identified inflammatory monocytes (F4/80+ Gr1+) as the responsible cell. CCL2 was critical for… CONTINUE READING
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