IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.

Abstract

Programmed cell death-1 (PD-1) is an inhibitory coreceptor for T lymphocytes that provides feedback inhibition of T cell activation. Although PD-1's expression on T cells is known to be activation dependent, the factors that determine the timing, intensity, and duration of PD-1 expression in immune reactions are not fully understood. To address this… (More)
DOI: 10.4049/jimmunol.1003208

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