IFN-α and lipopolysaccharide upregulate APOBEC3 mRNA through different signaling pathways.

  title={IFN-α and lipopolysaccharide upregulate APOBEC3 mRNA through different signaling pathways.},
  author={Harshini V. Mehta and Philip Jones and Jerrold P Weiss and Chioma M. Okeoma},
  journal={Journal of immunology},
  volume={189 8},
APOBEC3 (A3) proteins are virus-restriction factors that provide intrinsic immunity against infections by viruses like HIV-1 and mouse mammary tumor virus. A3 proteins are inducible by inflammatory stimuli, such as LPS and IFN-α, via mechanisms that are not fully defined. Using genetic and pharmacological studies on C57BL/6 mice and cells, we show that IFN-α and LPS induce A3 via different pathways, independently of each other. IFN-α positively regulates mouse APOBEC3 (mA3) mRNA expression… CONTINUE READING
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