IFN-α and IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4, and IRF-8 gene expression in human NK and T cells

@inproceedings{Lehtonen2003IFNAI,
  title={IFN-α and IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4, and IRF-8 gene expression in human NK and T cells},
  author={Anne Lehtonen and R J Lund and Riitta Lahesmaa and Ilkka Julkunen and Timo Sareneva and Sampsa Matikainen},
  year={2003}
}
Abstract IFN-α and IL-12 are macrophage-derived cytokines that enhance innate and Th1 immune responses. However, there is little information regarding IFN-α and IL-12 target genes that would be involved in mediating the immunostimulatory effects of these cytokines. The interferon regulatory factor (IRF) family of transcription factors is known to be involved in controlling lymphocyte differentiation and functions. In this work we have studied the effect of IFN-α and IL-12 on the expression of… CONTINUE READING

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