IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine.

@article{Mohr2010IFNgammaPB,
  title={IFN-\{gamma\} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine.},
  author={Elodie Mohr and Adam F Cunningham and Kai-Michael Toellner and Saeeda Bobat and Ruth E. Coughlan and Roger A Bird and I. C. M. Maclennan and Karine Serre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 40},
  pages={17292-7}
}
Alum-precipitated protein (alum protein) vaccines elicit long-lasting neutralizing antibody responses that prevent bacterial exotoxins and viruses from entering cells. Typically, these vaccines induce CD4 T cells to become T helper 2 (Th2) cells that induce Ig class switching to IgG1. We now report that CD8 T cells also respond to alum proteins, proliferating extensively and producing IFN-γ, a key Th1 cytokine. These findings led us to question whether adoptive transfer of antigen-specific CD8… CONTINUE READING

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