IFN‐λ3 polymorphism indirectly influences NK cell phenotype and function during acute HCV infection

@inproceedings{Depla2016IFN3PI,
  title={IFN‐λ3 polymorphism indirectly influences NK cell phenotype and function during acute HCV infection},
  author={Marion Depla and Sandy Pelletier and Nathalie B{\'e}dard and Camille Brunaud and Julie Bruneau and Naglaa H Shoukry},
  booktitle={Immunity, inflammation and disease},
  year={2016}
}
INTRODUCTION Polymorphisms in the type III interferon IFN-λ3 and the killer cell immunoglobulin-like receptor (KIR) genes controlling the activity of natural killer (NK) cells can predict spontaneous resolution of acute hepatitis C virus (HCV) infection. We hypothesized that IFN-λ3 polymorphism may modulate NK cell function during acute HCV. METHODS We monitored the plasma levels of type III IFNs in relation to the phenotype and the function of NK cells in a cohort of people who inject drugs… CONTINUE READING