IFN‐β protects from vascular leakage via up‐regulation of CD73

@article{Ki2007IFNPF,
  title={IFN‐$\beta$ protects from vascular leakage via up‐regulation of CD73},
  author={J{\'a}n Ki{\vs}{\vs} and Gennady G. Yegutkin and Kaisa Koskinen and Timo Savunen and Sirpa Jalkanen and Marko Salmi},
  journal={European Journal of Immunology},
  year={2007},
  volume={37}
}
Changes in endothelial permeability are crucial in the pathogenesis of many diseases. Adenosine is one of the endogenous mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN‐β is a novel inducer of CD73. We found that pretreatment with IFN‐β dramatically improved the vascular barrier function in lungs after intestinal ischemia‐reperfusion injury in wild‐type animals… 
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