IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

@article{Shankaran2001IFNAL,
  title={IFN$\gamma$ and lymphocytes prevent primary tumour development and shape tumour immunogenicity},
  author={Vijay Shankaran and Hiroaki Ikeda and Allen T. Bruce and J. Michael White and Paul E. Swanson and Lloyd J. Old and Robert D. Schreiber},
  journal={Nature},
  year={2001},
  volume={410},
  pages={1107-1111}
}
Lymphocytes were originally thought to form the basis of a ‘cancer immunosurveillance’ process that protects immunocompetent hosts against primary tumour development, but this idea was largely abandoned when no differences in primary tumour development were found between athymic nude mice and syngeneic wild-type mice. However, subsequent observations that nude mice do not completely lack functional T cells and that two components of the immune system—IFNγ and perforin—help to prevent tumour… 
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