IFITM1 is a tight junction protein that inhibits hepatitis C virus entry.

@article{Wilkins2013IFITM1IA,
  title={IFITM1 is a tight junction protein that inhibits hepatitis C virus entry.},
  author={Courtney R Wilkins and Jessica Woodward and Daryl T. Y. Lau and Amy A Barnes and Michael Joyce and Nicola McFarlane and Jane A McKeating and D. Lorne Tyrrell and Michael Gale},
  journal={Hepatology},
  year={2013},
  volume={57 2},
  pages={461-9}
}
UNLABELLED Type 1 interferon (IFN) continues to be the foundation for the current standard of care combination therapy for chronic hepatitis C virus (HCV) infection, yet the component interferon-stimulated genes (ISGs) that mediate the antiviral actions of IFN are not fully defined. Interferon-induced transmembrane protein 1 (IFITM1) is an ISG product that suppresses early stage infection by a number of viruses through an unknown mechanism of action. Moreover, the actions of IFITM1 on HCV… CONTINUE READING

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