IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival.

@article{Wainwright2012IDOEI,
  title={IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival.},
  author={Derek A. Wainwright and Irina V. Balyasnikova and Alan L. Chang and Atique U. Ahmed and Kyung Sub Moon and Brenda M. Auffinger and Alex L. Tobias and Yu Han and Maciej S. Lesniak},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 22},
  pages={
          6110-21
        }
}
PURPOSE Glioblastoma multiforme (GBM) is an aggressive adult brain tumor with a poor prognosis. One hallmark of GBM is the accumulation of immunosuppressive and tumor-promoting CD4(+)FoxP3(+)GITR(+) regulatory T cells (Tregs). Here, we investigated the role of indoleamine 2,3 dioxygenase (IDO) in brain tumors and the impact on Treg recruitment. EXPERIMENTAL DESIGN To determine the clinical relevance of IDO expression in brain tumors, we first correlated patient survival to the level of IDO… CONTINUE READING
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