IDO-Competent-DCs Induced by IFN-γ Attenuate Acute Rejection in rat Liver Transplantation

  title={IDO-Competent-DCs Induced by IFN-γ Attenuate Acute Rejection in rat Liver Transplantation},
  author={Xing Sun and Zi-jun Gong and Zhao-wen Wang and Tao Li and Jin-yan Zhang and Hong-cheng Sun and Shuang Liu and Li Huang and Chen Huang and Zhi-hai Peng},
  journal={Journal of Clinical Immunology},
We established a stable rat model of liver transplantation using Sprague-Dawley rats and Wistar rats in order to investigate the role of the IDO gene in acute rejection after rat liver transplantation. IDO gene expression and IDO enzyme activity were quantified in liver syngeneic grafts and allografts using microdialysis-HPLC. Liver allografts were evaluated for IDO expression by histopathology. We measured liver function-related biomarkers in liver allografts which were re-infused with… CONTINUE READING
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