IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity.

  title={IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity.},
  author={Sarah Chiang and Britta Weigelt and Huei-Chi Wen and F. Bermejo - Pareja and Ashwini Raghavendra and Luciano G Martelotto and Kathleen A. Burke and Thais Basili and Anqi Li and Felipe C Geyer and Salvatore Piscuoglio and Charlotte K. Y. Ng and Achim A. Jungbluth and J{\"o}rg Balss and Stefan Pusch and Gabrielle M Baker and Kimberly S Cole and Andreas von Deimling and Julie M. Batten and Jonathan D. Marotti and Hwei-Choo Soh and Benjamin L McCalip and Jonathan Israel Serrano and Raymond Lim and Kalliopi P. Siziopikou and Song Ziwei Li Lu and Xiaolong Liu and Tarek Hammour and Edi Brogi and M Snuderl and Anthony John Iafrate and Jorge S Reis-Filho and Stuart J. Schnitt},
  journal={Cancer research},
  volume={76 24},
Solid papillary carcinoma with reverse polarity (SPCRP) is a rare breast cancer subtype with an obscure etiology. In this study, we sought to describe its unique histopathologic features and to identify the genetic alterations that underpin SPCRP using massively parallel whole-exome and targeted sequencing. The morphologic and immunohistochemical features of SPCRP support the invasive nature of this subtype. Ten of 13 (77%) SPCRPs harbored hotspot mutations at R172 of the isocitrate… CONTINUE READING
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