IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas.

  title={IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas.},
  author={Sumihito Nobusawa and Takuya Watanabe and Paul Kleihues and Hiroko Ohgaki},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={15 19},
PURPOSE To establish the frequency of IDH1 mutations in glioblastomas at a population level, and to assess whether they allow reliable discrimination between primary (de novo) glioblastomas and secondary glioblastomas that progressed from low-grade or anaplastic astrocytoma. EXPERIMENTAL DESIGN We screened glioblastomas from a population-based study for IDH1 mutations and correlated them with clinical data and other genetic alterations. RESULTS IDH1 mutations were detected in 36 of 407… CONTINUE READING
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