IDH1 mutation, a genetic alteration associated with adult gliomatosis cerebri.

  title={IDH1 mutation, a genetic alteration associated with adult gliomatosis cerebri.},
  author={Deepti Narasimhaiah and Catherine Miquel and Elisabeth Verhamme and Paul Descl{\'e}e and Guy Cosnard and Catherine Godfraind},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  volume={32 1},
Recently, mutations in IDH1 and IDH2 have been reported as an early and common genetic alteration in diffuse gliomas, being possibly followed by 1p/19q loss in oligodendrogliomas and TP53 mutations in astrocytomas. Lately, IDH1 mutations have also been identified in adult gliomatosis cerebri (GC). The aim of our study was to test the status of IDH1/2, p53 and of chromosomes 1 and 19 in a series of 12 adult and three pediatric GC. For all tumors, clinico-radiologic characteristics… CONTINUE READING
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