IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression.

@article{Zhang2016IDHMG,
  title={IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression.},
  author={Xiaoran Zhang and Aparana Rao and Paola Sette and Christopher Deibert and Alexander Pomerantz and Wi Jin Kim and Gary Kohanbash and Yigang Chang and Yongseok Park and Johnathan Anderson Engh and Jaehyuk Choi and Timothy Chan and Hideho Okada and Michael Lotze and Paola Grandi and Nduka M. Amankulor},
  journal={Neuro-oncology},
  year={2016},
  volume={18 10},
  pages={1402-12}
}
BACKGROUND Diffuse gliomas are poorly immunogenic, fatal brain tumors. The basis for insufficient antitumor immunity in diffuse gliomas is unknown. Gain-of-function mutations in isocitrate dehydrogenases (IDH1 and IDH2) promote diffuse glioma formation through epigenetic reprogramming of a number of genes, including immune-related genes. Here, we identify epigenetic dysregulation of natural killer (NK) cell ligand genes as significant contributors to immune escape in glioma. METHODS We… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Methylation of NKG 2 D ligands contributes to immune system evasion in acutemyeloid leukemia

  • A BaraganoRaneros, V Martin-Palanco, AF Fernandez
  • Genes Immun
  • 2015

Similar Papers

Loading similar papers…