IDBA-tran: a more robust de novo de Bruijn graph assembler for transcriptomes with uneven expression levels

Abstract

MOTIVATION RNA sequencing based on next-generation sequencing technology is effective for analyzing transcriptomes. Like de novo genome assembly, de novo transcriptome assembly does not rely on any reference genome or additional annotation information, but is more difficult. In particular, isoforms can have very uneven expression levels (e.g. 1:100), which… (More)
DOI: 10.1093/bioinformatics/btt219

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