ID2 and ID3 protein expression mirrors granulopoietic maturation and discriminates between acute leukemia subtypes

Abstract

The inhibitors of DNA binding (ID) inhibit basic helix-loop-helix transcription factors and thereby guide cellular differentiation and proliferation. To elucidate the involvement of IDs in hematopoiesis and acute leukemias (AL), we analyzed ID2 and ID3 expression in hematopoiesis and leukemic blasts in bone marrow biopsies (BMB). BMB of healthy stem cell… (More)
DOI: 10.1007/s00418-013-1169-7

Topics

6 Figures and Tables