ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver.

@article{Hou2009ID2O,
  title={ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver.},
  author={Tim Y Hou and Sarah M Ward and Joana Maria Murad and Nathan P. Watson and Mark A. Israel and Giles E. Duffield},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 46},
  pages={31735-45}
}
Id2 is a helix-loop-helix transcription factor gene expressed in a circadian manner in multiple tissues with a phase-locked relationship with canonical clock genes. Our previous studies have identified circadian phenotypes in Id2 null mice, including enhanced photo-entrainment and disruption of activity rhythms, and have demonstrated a potent inhibitory effect of ID proteins upon CLOCK-BMAL1 transactivation of clock gene and clock-controlled gene activity. We have now begun to explore the… CONTINUE READING
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