ICPL labeling strategies for proteome research.

@article{Lottspeich2011ICPLLS,
  title={ICPL labeling strategies for proteome research.},
  author={Friedrich Lottspeich and Josef Kellermann},
  journal={Methods in molecular biology},
  year={2011},
  volume={753},
  pages={
          55-64
        }
}
  • Friedrich Lottspeich, Josef Kellermann
  • Published in Methods in molecular biology 2011
  • Chemistry, Medicine
  • Stable isotope labeling in combination with mass spectrometry has emerged as a powerful tool to identify and quantify thousands of proteins within complex protein mixtures. Isotope-coded protein label (ICPL) is capable of high-throughput quantitative proteome profiling on a global scale. Since ICPL is based on stable isotope tagging at the free amino groups of intact proteins, it is applicable to any protein sample, including extracts from tissues or body fluids. After labeling of up to four… CONTINUE READING

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