ICP47 mediates viral neuroinvasiveness by induction of TAP protein following intravenous inoculation of herpes simplex virus type 1 in mice

@article{Burgos2006ICP47MV,
  title={ICP47 mediates viral neuroinvasiveness by induction of TAP protein following intravenous inoculation of herpes simplex virus type 1 in mice},
  author={Javier Santos Burgos and Esther Serrano-Saiz and Isabel Sastre and Fernando Valdivieso},
  journal={Journal of NeuroVirology},
  year={2006},
  volume={12},
  pages={420-427}
}
Herpes simplex virus type 1 (HSV-1) expresses an immediate-early protein, ICP47, that blocks the major histocompatibility complex class I antigen presentation pathway by binding to the transporter associated with antigen presentation (TAP). The result is the virus’ evasion of the immune system. Although the interaction between ICP47 and TAP has been examined in vitro, this paper is the first to report their interaction in vivo. In C57BL/6 adult female mice, ICP47-defective virus (ΔICP47, F… CONTINUE READING

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