ICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated.

@article{Blaho1991ICP4TM,
  title={ICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated.},
  author={John A. Blaho and Bernard Roizman},
  journal={Journal of virology},
  year={1991},
  volume={65 7},
  pages={3759-69}
}
Infected cell protein 4 (ICP4), the product of the alpha 4 gene, regulates herpes simplex virus 1 and herpes simplex virus 2 gene expression at the transcriptional level both positively and negatively. Previous studies have shown that ICP4 is extensively modified posttranslationally. We report that ICP4 was labeled in isolated nuclei of infected cells by… CONTINUE READING