ICP34.5 protein of herpes simplex virus facilitates the initiation of protein translation by bridging eukaryotic initiation factor 2alpha (eIF2alpha) and protein phosphatase 1.

@article{Li2011ICP345PO,
  title={ICP34.5 protein of herpes simplex virus facilitates the initiation of protein translation by bridging eukaryotic initiation factor 2alpha (eIF2alpha) and protein phosphatase 1.},
  author={Yapeng Li and Cui-zhu Zhang and Xiangdong Chen and Jia Yu and Yu Wang and Yin Yang and Mingjuan Du and Huali Jin and Yijie Ma and Bin He and Youjia Cao},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 28},
  pages={24785-92}
}
The ICP34.5 protein of herpes simplex virus type 1 is a neurovirulence factor that plays critical roles in viral replication and anti-host responses. One of its functions is to recruit protein phosphatase 1 (PP1) that leads to the dephosphorylation of the α subunit of translation initiation factor eIF2 (eIF2α), which is inactivated by infection-induced phosphorylation. As PP1 is a protein phosphatase with a wide range of substrates, the question remains to be answered how ICP34.5 directs PP1 to… CONTINUE READING

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Interacts with eIF2 24792 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

K. Yang, B. He
J. Virol • 2003

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