ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties

@article{Liu2003ICP345DH,
  title={ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties},
  author={Baolin Liu and Michael Robinson and Z Han and Ruth Branston and Chris English and P. F. Reay and Yvonne McGrath and Sharon K Thomas and Mark Thornton and Paula Bullock and Colin A. Love and Robert S. Coffin},
  journal={Gene Therapy},
  year={2003},
  volume={10},
  pages={292-303}
}
Herpes simplex virus type-1 (HSV1) in which the neurovirulence factor ICP34.5 is inactivated has been shown to direct tumour-specific cell lysis in several tumour models. Such viruses have also been shown to be safe in Phase I clinical trials by intra-tumoral injection in glioma and melanoma patients.1,2,3 Previous work has used serially passaged laboratory isolates of HSV1 which we hypothesized may be attenuated in their lytic capability in human tumour cells as compared to more recent… CONTINUE READING
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