ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression.

@article{Poon2006ICP0AT,
  title={ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression.},
  author={Alice P. W. Poon and Haidong Gu and Bernard Roizman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 26},
  pages={9993-8}
}
SK-N-SH cells exposed to low ratios of ICP0-null (DeltaICP0) mutants of herpes simplex virus per cell express the viral alpha proteins, but the progression to beta and gamma gene expression does not ensue. In these restrictive cells, post-alpha gene expression can be induced after exposure of the infected cells to sodium butyrate, an indication that VP16 brought into cells by the virus and the alpha gene products made after infection cannot block the silencing of viral post-alpha genes by… CONTINUE READING

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