ICP0 Dismantles Microtubule Networks in Herpes Simplex Virus-Infected Cells

@inproceedings{Liu2010ICP0DM,
  title={ICP0 Dismantles Microtubule Networks in Herpes Simplex Virus-Infected Cells},
  author={MingYu Liu and Edward E Schmidt and William P. Halford},
  booktitle={PloS one},
  year={2010}
}
Infected-cell protein 0 (ICP0) is a RING finger E3 ligase that regulates herpes simplex virus (HSV) mRNA synthesis, and strongly influences the balance between latency and replication of HSV. For 25 years, the nuclear functions of ICP0 have been the subject of intense scrutiny. To obtain new clues about ICP0's mechanism of action, we constructed HSV-1 viruses that expressed GFP-tagged ICP0. To our surprise, both GFP-tagged and wild-type ICP0 were predominantly observed in the cytoplasm of HSV… CONTINUE READING

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