ICOS ligand expression is essential for allergic airway hyperresponsiveness.

  title={ICOS ligand expression is essential for allergic airway hyperresponsiveness.},
  author={Kamran Kadkhoda and Shuhe Wang and Yijun Fan and Hongyu Qiu and Sujata Basu and Andrew J Halayko and Xi Yang},
  journal={International immunology},
  volume={23 4},
Inducible co-stimulator ligand (ICOSL) is a rather newly defined co-stimulatory molecule, which, through interaction with ICOS expressed on T cells, plays an important role in T-cell activation, differentiation and function. T(h)2-type immune responses are critical for the development and maintenance of allergic responses including asthma. Using knockout (KO) mice, we have assessed the role of ICOSL in allergic airway inflammation and responsiveness using a standard mouse asthma model induced… CONTINUE READING